474
Treatment outcomes for gallbladder carcinoma at Viet Duc University Hospital from 2015 to 2022
136
Số 03 - Tập 15 - Năm 2025
https://doi.org/10.51199/vjsel.2025.3.1
https://doi.org/10.51199

Treatment outcomes for gallbladder carcinoma at Viet Duc University Hospital from 2015 to 2022

Tran Dinh Tho
Tran Dinh Tho
Tác giả chính
Nguyen Hai Nam
Nguyen Hai Nam
Đồng tác giả
Nguyen Thi Lan
Nguyen Thi Lan
Đồng tác giả
Nguyen Thu Ha
Nguyen Thu Ha
Đồng tác giả
Chu Minh Phuc
Chu Minh Phuc
Đồng tác giả
Ngày đăng:26/10/2025
https://doi.org/10.51199/vjsel.2025.3.1
4.203 Lượt xem
850 Lượt tải
12 Trích dẫn
98 Chia sẻ

Abstract


Introduction:

Gallbladder carcinoma (GBC) is a rare but aggressive tumor. Operability is crucial for survival, yet late-stage diagnosis is common due to its asymptomatic nature. This study evaluates the clinical features and surgical outcomes of GBC treatment.



Patients and Methods:

A retrospective study was conducted on GBC patients who underwent surgery at Viet Duc University Hospital (2015–2022). Inoperable cases and those with incomplete records were excluded. Clinical characteristics, surgical details, and outcomes were analyzed.



Results:

Among 41 patients, most were diagnosed at advanced stages, with T3 being the most common stage (51.2%). Open surgery (51.2%) was slightly more frequent than laparoscopic procedures. Cholecystectomy alone was performed in 31.7%, while others required hepatectomy or lymphadenectomy. The average hospital stay was 8 ± 3.5 days, with complications occurring in 3 cases and one postoperative death. Mid-term survival was poor, with 31.7% surviving less than six months and 29.3% living for 1–3 years.



Conclusions:

GBC is often diagnosed late, limiting surgical success and survival. Despite surgical resection, prognosis remains poor, highlighting the need for earlier detection and improved treatment strategies.

Abbreviations:

GBC: Gallbladder carcinoma, CT: Computed tomography, MRI: Magnetic resonance imaging, CA 19-9: Carbohydrate antigen 19-9, CEA: Carcinoembryonic antigen



Keywords:
Gallbladder cancer, surgical treatment, mid-term survival

References

  1. Baria K, De Toni EN, Yu B, Jiang Z, Kabadi SM, Malvezzi M. Worldwide Incidence and Mortality of Biliary Tract Cancer. Gastro Hep Adv. 2022;1(4):618-626. doi:10.1016/j.gastha.2022.04.007
  2. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67(1):7-30. doi:10.3322/caac.21387
  3. Goetze TO. Gallbladder carcinoma: Prognostic factors and therapeutic options. World J Gastroenterol. 2015;21(43):12211-12217. doi:10.3748/wjg.v21.i43.12211
  4. Nguyen TP, Luu HN, Nguyen MVT, et al. Attributable Causes of Cancer in Vietnam. JCO Glob Oncol. 2020;6:JGO.19.00239. doi:10.1200/JGO.19.00239
  5. Hundal R, Shaffer EA. Gallbladder cancer: epidemiology and outcome. Clin Epidemiol. 2014;6:99-109. doi:10.2147/CLEP.S37357
  6. Strom BL, Maislin G, West SL, et al. Serum CEA and CA 19-9: potential future diagnostic or screening tests for gallbladder cancer? Int J Cancer. 1990;45(5):821-824. doi:10.1002/ijc.2910450505
  7. Agarwal AK, Kalayarasan R, Javed A, Gupta N, Nag HH. The role of staging laparoscopy in primary gall bladder cancer--an analysis of 409 patients: a prospective study to evaluate the role of staging laparoscopy in the management of gallbladder cancer. Ann Surg. 2013;258(2):318-323. doi:10.1097/SLA.0b013e318271497e
  8. Zhou D, Wang J, Quan Z, Yang Y, Ma F. Improvement in the diagnosis and treatment of T2 gallbladder carcinoma is pivotal to improvement in the overall prognosis for this disease. Biosci Trends. 2019;13(1):1-9. doi:10.5582/bst.2019.01039
  9. Maplanka C. Gallbladder cancer, treatment failure and relapses: the peritoneum in gallbladder cancer. J Gastrointest Cancer. 2014;45(3):245-255. doi:10.1007/s12029-014-9597-8
  10. Morgan MA. Bile duct dilatation | Radiology Reference Article | Radiopaedia.org. Radiopaedia. doi:10.53347/rID-34179
  11. Gaillard F. Lymph node enlargement | Radiology Reference Article | Radiopaedia.org. Radiopaedia. doi:10.53347/rID-2752
  12. Truong PH, Clinical, Paraclinical, Pathological and Surgical Outcomes for Gallbladder Cancer, Sub-specialist Thesis, Hanoi Medical University, 2008
  13. Do MH, Treatment Outcome for Gallbladder Cancer at Viet Duc University Hospital, Master thesis, Hanoi Medical University, 2021
  14. Rathanaswamy S, Misra S, Kumar V, et al. Incidentally Detected Gallbladder Cancer- The Controversies and Algorithmic Approach to Management. Indian J Surg. 2012;74(3):248-254. doi:10.1007/s12262-012-0592-7
  15. Sachan A, Saluja SS, Nekarakanti PK, et al. Raised CA19–9 and CEA have prognostic relevance in gallbladder carcinoma. BMC Cancer. 2020;20(1):826. doi:10.1186/s12885-020-07334-x
  16. Park YJ, Hwang S, Kim KH, et al. Prognosis of patients with pT1b/T2 gallbladder carcinoma who have undergone laparoscopic cholecystectomy as an initial operation. Korean J Hepato-Biliary-Pancreat Surg. 2013;17(3):113-117. doi:10.14701/kjhbps.2013.17.3.113
  17. Watson H, Dasari B, Wyatt J, et al. Does a second resection provide a survival benefit in patients diagnosed with incidental T1b/T2 gallbladder cancer following cholecystectomy? HPB. 2017;19(2):104-107. doi:10.1016/j.hpb.2016.11.006
  18. Alrawashdeh W, Kamarajah SK, Gujjuri RR, et al. Systematic review and meta-analysis of survival outcomes in T2a and T2b gallbladder cancers. HPB. 2022;24(6):789-796. doi:10.1016/j.hpb.2021.12.019
  19. Balakrishnan A, Barmpounakis P, Demiris N, et al. Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study. eClinicalMedicine. 2023;59. doi:10.1016/j.eclinm.2023.101951
  20. Feng X, Cao JS, Chen MY, et al. Laparoscopic surgery for early gallbladder carcinoma: A systematic review and meta-analysis. World J Clin Cases. 2020;8(6):1074-1086. doi:10.12998/wjcc.v8.i6.1074
  21. Vogel A, Bridgewater J, Edeline J, et al. Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2023;34(2):127-140. doi:10.1016/j.annonc.2022.10.506
  22. Zhao X, Li XY, Ji W. Laparoscopic versus open treatment of gallbladder cancer: A systematic review and meta-analysis. J Minimal Access Surg. 2018;14(3):185-191. doi:10.4103/jmas.JMAS_223_16
  23. Lee BJH, Yap QV, Low JK, Chan YH, Shelat VG. Cholecystectomy for asymptomatic gallstones: Markov decision tree analysis. World J Clin Cases. 2022;10(29):10399-10412. doi:10.12998/wjcc.v10.i29.10399
  24. Mathur AV. Need for Prophylactic Cholecystectomy in Silent Gall Stones in North India. Indian J Surg Oncol. 2015;6(3):251-255. doi:10.1007/s13193-015-0418-8
  25. Prabhu RS, Hwang J. Adjuvant therapy in biliary tract and gall bladder carcinomas: a review. J Gastrointest Oncol. 2017;8(2):302-313. doi:10.21037/jgo.2017.01.17.

Inverted kidney transplantation in patients with iliac atherosclerosis: Experiences from three cases and literature review

Tác giả:
Hoang Tuan
Do Hai Dang
Duong Duc Hung
Ninh Viet Khai
Số 03 - Tập 15 - Năm 2025Ngày đăng: 26/10/2025

AbstractKidney transplantation (KT) provided the best outcomes for patients with end-stage renal disease. Inverted kidney transplantation in which the renal pelvis orientation is reversed upward, is a technique initially used for right kidney transplants with short renal veins placed into the right iliac fossa. Consequently, the use of inverted KT was limited to cases of severe iliac atherosclerosis. This study evaluates the outcomes of inverted KT in patients with iliac atherosclerosis. We retrospectively analyzed three patients who underwent inverted KT from living donors at Viet Duc University Hospital due to iliac atherosclerosis. We performed the vessel anastomoses at the non-atherosclerotic...

https://doi.org/10.51199/vjsel.2025.3.2

Results of laparoscopic cholecystectomy for acute calculous cholecystitis following percutaneous transhepatic gallbladder drainage at Le Van Thinh Hospital

Tác giả:
Nguyen Hong Son
Hoang Dinh Tuy
Cao Pham Thanh Duy
Tran Duc Huy
Số 03 - Tập 15 - Năm 2025Ngày đăng: 26/10/2025

Abstract Introduction: Percutaneous transhepatic gallbladder drainage (PTGBD) is a safe, effective initial treatment for acute cholecystitis in high-risk patients. Laparoscopic cholecystectomy (LC) is the definitive treatment. This study evaluates the feasibility and optimal timing of LC post-PTGBD at Le Van Thinh Hospital, as outcomes may be similar regardless of surgical timing. Patients and Methods: A prospective descriptive case series was conducted from January 2022 to June 2024 at the General Surgery Department of Le Van Thinh Hospital. Patients diagnosed with grade II, III acute calculous cholecystitis who underwent PTGBD followed by LC were included. Patients were categorized into two groups...

https://doi.org/10.51199/vjsel.2025.3.3

Long-term outcomes of laparoscopic hepatectomy for hepatocellular carcinoma at Viet Duc University Hospital from 2019 to 2023

Tác giả:
Nguyen Quang Nghia
Tran Xuan Cong
Tran Dinh Dung
Ninh Viet Khai
Tran Ha Phuong
Hoang Tuan
Do Hai Dang
Nguyen Huy Toan
Số 03 - Tập 15 - Năm 2025Ngày đăng: 26/10/2025

Abstract Introduction: Laparoscopic liver resection is a challenging procedure, yet it is increasingly applied in the treatment of hepatocellular carcinoma (HCC), including our center. Our aim is to evaluate the impact of laparoscopic hepatectomy for hepatocellular carcinoma regarding the long-term outcomes. Patients and Methods: A combined retrospective-prospective cohort study of 41 HCC patients who underwent laparoscopic hepatectomy at the Organ Transplantation Center, Viet Duc University Hospital from January 2019 to December 2023. Results: Liver resection for tumors >5 cm accounted for 24.4%, with 63.4% of cases classified as high difficulty (Ban Daisuke score). The mean operative time was 192 minutes,...

https://doi.org/10.51199/vjsel.2025.3.4

Long-term outcomes of surgical resection and adjuvant chemotherapy in gastric stromal tumors

Tác giả:
Nguyen Anh Tuan
Pham Van Hiep
Hoang Van Son
Số 03 - Tập 15 - Năm 2025Ngày đăng: 26/10/2025

Abstract Introduction: Gastric stromal tumors are a relatively common group of neoplasms. This study is aimed to evaluate treatment outcomes in patients with gastric stromal tumors who underwent surgery and adjuvant treatment at 108 Military Central Hospital Patients and Methods: This study included 60 patients with gastric stromal tumors who underwent surgery and adjuvant treatment at 108 Military Central Hospital from January 2021 to December 2023. A cross-sectional descriptive study was conducted to assess clinical and paraclinical characteristics, and to evaluate the outcomes of surgical treatment and postoperative adjuvant therapy. Results: The male/female ratio was 1.4:1, and the average age...

https://doi.org/10.51199/vjsel.2025.3.5

Anatomical variations of the hepatic artery in liver grafts from brain-dead donors

Tác giả:
Duong Duc Hung
Nguyen Thanh Khiem
Luong Tuan Hiep
Số 03 - Tập 15 - Năm 2025Ngày đăng: 26/10/2025

Abstract Introduction: The anatomical variations of the hepatic artery are a critical consideration in liver transplantation, impacting both surgical planning and postoperative outcomes. This study aimed to identify and classify hepatic artery variations in liver grafts procured from brain-dead donors at Viet Duc Hospital and to evaluate their implications for transplantation. Patients and Methods: Data were collected retrospectively from 2011 to 2016 and prospectively from 2017 to 2020, covering 53 liver grafts obtained from brain-dead donors. Results: Anatomical variants were categorized according to Hiatt’s classification and additional atypical patterns, with Type 1 (67.9%) being the most common, followed by Type...

https://doi.org/10.51199/vjsel.2025.3.6

One-nostril endoscopic endonasal approach for pituitary macroadenoma resection

Tác giả:
Duong Dai Ha
Pham Hoang Anh
Vu Trung Hai
Le Duc Tam
Nguyen Duy Hieu
Số 03 - Tập 15 - Năm 2025Ngày đăng: 26/10/2025

Abstract Introduction: Endoscopic techniques have become the standard approach for pituitary adenoma surgery, providing improved visualization of the hypophyseal fossa and facilitating precise tumor resection while minimizing surgical morbidity. The one-nostril endoscopic approach further enhances minimally invasive surgery by reducing nasal mucosal trauma and optimizing access to the tumor, thereby improving surgical precision and reducing the risk of postoperative complications Patients and Methods: Between September 2024 and February 2025, a retrospective analysis was conducted on 12 consecutive patients who underwent one-nostril endoscopic transsphenoidal surgery at Viet Duc University Hospital and Hanoi Medical University. Furthermore, we provide a step-by-step description of...

https://doi.org/10.51199/vjsel.2025.3.7